Pakistan’s Ranking in Social Development: Have We Always Been Backward?

We Have Always Been . . . Cyborgs

philosophy of mathematics suited well the ‘‘general emphasisin later nineteenth-century mathematics on revisiting foundationalquestions’’ (p. 61). Pure geometry as it emerged from Frege, Paschand Hilbert, provided a diagram-free, purely sentential notion ofproof, which has lasted unto our own day.In the second, and greater, part of the book, Greaves traces outthe interre...

I-36: Preimplantation Genetic Diagnosis - Where Have We Been and Where Are We Going

Preimplantation genetic diagnosis (PGD) is now considered routine in IVF laboratories with micromanipulation capability and access to genetic diagnostic services. The past two decades have witnessed a dramatic increase in the use of PGD, the number of cycles performed, and the indications for which PGD has been used. This increase has been mirrored by a slow, but steady, increase in the range o...

Where we have been, where we are going.

Osteoarthritis: what we have been missing in the patellofemoral joint.

Patellofemoral osteoarthritis is common clinically and often independent of tibiofemoral disease. Intriguingly, the patella demonstrates more severe degeneration earlier in the disease process compared with the juxtaposed femoral groove. Here, we consider three hypotheses influencing this disparity and thus discover crucial insights into the etiology of osteoarthritis.

Depression in Diabetes: Have We Been Missing Something Important?

An extensive literature has developed to suggest that depression is more common in patients with diabetes than in the general population (1) and is associated with chronic hyperglycemia (2), risk for diabetes complications (3), and mortality (4). Although the causal linkages among these relationships have not been demonstrated, their consistency has led to calls for intensive efforts to identif...